Vasc-on-Demand

Our Technology

technology

Functionality

The fabrication of perfusable and functional vascular networks remains a major challenge in tissue engineering, despite their importance for cell survival, barrier function, drug testing, and reducing animal use. The EU-funded project Vasc-on-Demand addresses this by developing standardized consumables for the straightforward generation, perfusion, and cultivation of blood vessels, with perfusion chambers designed in the classical well plate format to ensure broad compatibility. With these products, we also help to tackle one of the biggest challenges in drug testing: the 90% failure rate of drug candidates in clinical studies, by providing more human-relevant models that improve predictive accuracy in preclinical testing.

The Vasc Platform offers a full spectrum of plug-and-play vascular tissue solutions – each step combining greater simplicity with higher physiological relevance.

BasicVasc

basic

Functionality

BasicVasc uses vasculature-mimicking sacrificial templates embedded in a user-known well plate. By adding an extracellular matrix and user-defined cells, followed by scaffold removal via temperature reduction, vascularized tissues can be created with ease. The platform enables centimeter-scale vascularized tissues without membranes or plastics within the living constructs.

General Applications

How to utilize BasicVasc in the lab.

Compatibility

Vascularized tissues can be monitored during culture and removed for endpoint analysis.

Properties of the vascularized tissue

BasicVasc can be utilized to generate vascularized perfusable tissue models with your specific cell types that help you solve your scientific questions.

General Applications

Current Applications

Our platform technology is already used for the following funded projects and tissues.

Leaky vessels

Vascular leakage is a critical parameter in in vitro drug testing, as it reflects how compounds affect endothelial barrier integrity and can predict inflammation, toxicity, and delivery efficiency in human tissues.

Leaky Vascularized liver model

A vascularized liver model is essential for in vitro drug testing because it replicates physiologically relevant perfusion and hepatovascular interactions, enabling more accurate predictions of metabolism, toxicity, and therapeutic responses.
Learn more

Blood-brain-barrier/tumor

A blood–brain barrier model for glioblastoma is crucial because it captures the unique barrier properties and tumor–vascular interactions that determine drug penetration, treatment resistance, and therapeutic efficacy.
Learn more

More to come!

A vascular bone model enables more realistic testing of bone regeneration, remodeling, and drug delivery.

A vascularized fat model allows more accurate studies of adipose function, metabolism, and drug responsiveness.

A vascularized skin model supports more realistic evaluation of wound healing, inflammation, and topical drug effects.

We are currently looking for collaborators and prototype testers. Contact us!

EasyVasc

easy

Functionality

EasyVasc is our next-generation vascular channel system, offering suspended, stable channels built on a biological matrix, setting it apart from BasicVasc. It is compatible with weak hydrogels such as collagen, fibrin, and Matrigel, making it easy to integrate into soft tissue models.The workflow is greatly simplified: no sacrificial scaffold removal is required. Plus, EasyVasc is shipped freeze-dried for convenient storage and immediate use.

CompleteVasc

complete

Functionality

CompleteVasc builds on EasyVasc by incorporating blood vessel cells—such as smooth muscle cells and pericytes—directly into the vessel wall. With endothelial cells forming a confluent lining inside the channels, CompleteVasc provides fully perfusable human blood vessels as ready-to-use building blocks for vascularized tissue models. It offers the same convenient usability as EasyVasc and is fully compatible with our platform technology. CompleteVasc is shipped frozen for straightforward storage and immediate application.

Current Developments

developments

TEER compatibility

TEER (Trans Epithelial Electrical Resistance) enables researchers to monitor barrier integrity and function directly within our vascular models. Adding TEER measurement provides a quantitative readout of endothelial performance, supporting more precise and physiologically relevant assessments.

Insert technology

The adaptation of our perfusable tissues to inserts enables simpler and more convenient handling. This format improves compatibility with existing model systems and workflows, making integration into established assays far easier. It enhances usability while maintaining the full functionality of our perfusable tissue models.

Unidirectional perfusion

We are advancing our technology by adding a new unidirectional perfusion capability as an extension to our existing system. By integrating bioreactors and chip-based formats that connect to standard pumping systems, we enable more physiological flow conditions while specifically addressing the limitations of bidirectional perfusion.
This new development enhances our portfolio by supporting even more in vivo-like substance transport and tissue behavior, further improving physiological relevance—without disrupting established workflows or compatibility with existing perfusion setups. Seamless integration into current perfusion infrastructures remains fully preserved.